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As of Wednesday, May 7, 2025, it’s challenging to provide an exact real-time count of all publicly traded companies specifically headquartered in San Diego County. This number fluctuates due to IPOs, mergers, acquisitions, and companies moving their headquarters.
However, based on available information and lists, here are some of the publicly traded companies with a significant presence or headquarters in San Diego County, categorized by their primary listing exchange:
NASDAQ:
* Illumina Inc. (ILMN): A major biotechnology company.
* Qualcomm Inc. (QCOM): A global leader in wireless technology.
* Dexcom, Inc. (DXCM): A medical device company focused on continuous glucose monitoring systems.
* ResMed Inc. (RMD): While headquartered in Poway (North San Diego County), it’s listed on the NYSE but has a significant presence.
* Organovo Holdings, Inc. (ONVO): A clinical-stage biotechnology company.
* Revelation Biosciences, Inc. (REVB): A clinical-stage life science company.
* Biora Therapeutics, Inc. (BIOR): A biotech company focused on therapeutic delivery.
* Southern California Bancorp (BCAL): A bank holding company headquartered in San Diego.
* Xtant Medical Holdings, Inc. (XTNT): A medical device company.
* AirJoule Technologies Corporation (AIRJ): Industrials sector.
NYSE:
* Sempra Energy (SRE): An energy infrastructure company.
* San Diego Gas & Electric Company (SDG): A subsidiary of Sempra Energy.
* Realty Income Corp. (O): A real estate investment trust (REIT) based in Escondido (North San Diego County).
* BioMed Realty Trust Inc. (BMR): A REIT focused on life science real estate (located in Rancho Bernardo, North San Diego County).
* Callaway Golf Co. (ELY): A major golf equipment company based in Carlsbad (North San Diego County).
* First American Financial Corporation (FAF): While headquartered in Santa Ana, has a significant presence and operations in San Diego.
Important Considerations:
* Headquarters vs. Operations: Some companies may have significant operations or a large employee base in San Diego County but have their headquarters elsewhere.
* Subsidiaries: Some listed entities might have major subsidiaries located in San Diego County.
* Fluctuations: The list can change due to market events.
* North County: Several publicly traded companies are located in the northern part of San Diego County (e.g., Carlsbad, Poway, Escondido, Rancho Bernardo).
To get a precise, real-time number, you would typically need to use financial data providers or screeners that allow filtering by geographic location. However, the companies listed above represent a significant portion of the publicly traded entities with a strong connection to San Diego County.

Video courtesy of Interactive Brokers

Video courtesy of Interactive Brokers